Problems in E rickson et al. 2009

Problems in Erickson et al. 2009

In the course of pursuing research on dinosaur growth rates (Myhrvold, 2013), I attempted to repli-cate the findings of Erickson et al. for Psittacosaurus lujiatunensis (Erickson et al., 2009a). In their study, they use femoral length measurements and age estimates for 80 specimens of P. lujiatunensis to estimate body mass and age, fit a growth curve, and construct a life table. These results w...

Article by Kerdiles Y.M. et al. Nature Immunology, 2009

Foxo transcription factors have a conserved role in the adaptation of cells and organisms to nutrient and growth factor availability. Here we show that Foxo1 has a crucial, nonredundant role in T cells. In naive T cells, Foxo1 controlled the expression of the adhesion molecule L-selectin, the chemokine receptor CCR7 and the transcription factor Klf2, and its deletion was sufficient to alter lym...

Article by O. Schulz et al. JEM 2009

The Rockefeller University Press $30.00 J. Exp. Med. Vol. 206 No. 13 3101-3114 www.jem.org/cgi/doi/10.1084/jem.20091925 3101 The intestinal mucosa contains large numbers of mononuclear cells, including macrophages and DCs, which together are believed to play a central role in regulating mucosal innate and adaptive immune responses in both the steadystate and inflammatory setting (Kelsall, 2008)...

Article by R.L. Reinhardt et al. Nat. Med. 2009

High-affinity antibodies are critical for host protection and underlie successful vaccines. The generation of such antibodies requires T cell–dependent help, which mediates germinal center reactions in which mutation and selection of B cells occurs. Using an interleukin 4–reporter system, we show here that CD4+ follicular helper T cells constituted essentially all of the cytokine-secreting T ce...

In Response to Murphy et al., Löwer et al., and Lan et al